The Novel bis-1,2,4-Triazine MIPS-0004373 Demonstrates Rapid and Potent Activity against All Blood Stages of the Malaria Parasite-Reference-Cited by-同舟云学术

The Novel bis-1,2,4-Triazine MIPS-0004373 Demonstrates Rapid and Potent Activity against All Blood Stages of the Malaria Parasite

Published:2021-10-18 Issue:11 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ellis Katherine M.¹,Lucantoni Leonardo²,Chavchich Marina³^ORCID,Abraham Matthew⁴,De Paoli Amanda¹,Luth Madeline R.⁴,Zeeman Anne-Marie⁵,Delves Michael J.⁶,Terán Fernando Sánchez-Román⁶,Straschil Ursula⁶,Baum Jake⁶^ORCID,Kocken Clemens H. M.⁵,Ralph Stuart A.⁷^ORCID,Winzeler Elizabeth A.⁴,Avery Vicky M.²,Edstein Michael D.³,Baell Jonathan B.⁸,Creek Darren J.¹^ORCID

Affiliation:

1. Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia

2. Discovery Biology, Griffith University, Nathan, QLD, Australia

3. The Department of Drug Evaluation, Australian Defence Force Malaria and Infectious Disease Institute, Brisbane, QLD, Australia

4. School of Medicine, University of California, San Diego, La Jolla, California, USA

5. Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, Netherlands

6. Department of Life Sciences, Imperial College London, South Kensington, London, United Kingdom

7. Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, Australia

8. Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia

Abstract

Novel bis-1,2,4-triazine compounds with potent in vitro activity against Plasmodium falciparum parasites were recently identified. The bis-1,2,4-triazines represent a unique antimalarial pharmacophore and are proposed to act by a novel but as-yet-unknown mechanism of action.

Funder

Department of Health, Australian Government | National Health and Medical Research Council

Medicines for Malaria Venture

Wellcome

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00311-21

Reference45 articles.

1. Noor A, Aponte J, Aregawi M, Barrette A, Biondi N, Knox T, Patouillard E, Williams R. 2017. World Malaria Report 2017. WHO, Geneva, Switzerland.