Antimalarial Activity of Tigecycline, a Novel Glycylcycline Antibiotic-Reference-Cited by-同舟云学术

Antimalarial Activity of Tigecycline, a Novel Glycylcycline Antibiotic

Published:2009-09 Issue:9 Volume:53 Page:4040-4042
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Starzengruber P.¹²,Thriemer K.¹²,Haque R.³,Khan W. A.³,Fuehrer H. P.¹²,Siedl A.¹²,Hofecker V.¹²,Ley B.¹²,Wernsdorfer W. H.¹,Noedl H.¹²

Affiliation:

1. Department of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria

2. MARIB, Malaria Research Initiative Bandarban, Bandarban, Bangladesh

3. International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh

Abstract

ABSTRACT Tigecycline is a novel glycylcycline antibiotic with a broad antibacterial spectrum. Tigecycline was tested with 66 clinical isolates of Plasmodium falciparum from Bangladesh using the histidine-rich protein 2 in vitro drug susceptibility assay. The 50% and 90% inhibitory concentrations of tigecycline were 699 (95% confidence interval, 496 to 986) and 5,905 nM (4,344 to 8,028). Tigecycline shows no activity correlation with traditional antimalarials and has substantial antimalarial activity on its own.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00312-09

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