Author:
Brogard J M,Arnaud J P,Blickle J F,Lavillaureix J
Abstract
Apalcillin was administered intravenously as a single 1-g dose on day 8 after surgery to 10 cholecystectomized patients with T-tube drainage. A peak of 2,093 +/- standard error of the mean 859 micrograms/ml of bile was attained at 3 h after dosage. Biliary recovery over a 12-h period amounted to 12.2% of the dose. In 20 patients undergoing biliary surgery, apalcillin concentrations 1 h after a 1-g dose were 65.5 +/- 5.0, 3,680 +/- 551, and 2,552 +/- 627 micrograms/ml in serum, choledochal bile, and gallbladder bile, respectively.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference6 articles.
1. PC-904, a new semisynthetic penicillin;Bodey G. P.;Antimicrob. Agents Chemother.,1978
2. Brograd J. M. 1980. Agents antimicrobiens et voies biliaires. Dossiers Clin-Midy vol. 1. Laboratoires Clin-Midy Paris.
3. Biliary elimination of mezlocillin: an experimental and clinical study;Brogard J. M.;Antimicrob. Agents Chemother.,1980
4. Laboratoires Frangais de ThErapeutique. Apalcillin PC 904. Summary of several studies. Laboratoires Francais de Therapeutique Bordeaux France.
5. In vitro activity of apalcillin compared with that of other new penicillins and anti-Pseudomonas cephalosporins;Neu H. C.;Antimicrob. Agents Chemother.,1982
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