The Small Protein CydX Is Required for Cytochrome bd Quinol Oxidase Stability and Function in Salmonella enterica Serovar Typhimurium: a Phenotypic Study

Author:

Duc Kieu Minh1ORCID,Kang Bo Gyeong1,Lee Choa1,Park Hee Jeong1,Park Yoon Mee1,Joung Young Hee2,Bang Iel Soo1

Affiliation:

1. Department of Microbiology and Immunology, Chosun University School of Dentistry, Gwangju, Republic of Korea

2. School of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea

Abstract

Cytochrome bd quinol oxidases, which are found only in bacteria, govern the fitness of many facultative anaerobic pathogens by promoting respiration in low-oxygen environments and by conferring resistance to antimicrobial radicals. Thus, cytochrome bd complex assembly and activity are considered potential therapeutic targets. Here we report that the small protein CydX is required for the assembly and function of the cytochrome bd complex in S . Typhimurium under stress conditions, including exposure to β-mercaptoethanol, nitric oxide, or the phagocytic intracellular environment, demonstrating its crucial function for Salmonella fitness. However, cytochrome bd inactivation also leads to increased resistance to some antibiotics, so considerable caution should be taken when developing therapeutic strategies targeting the CydX-dependent cytochrome bd .

Funder

National Research Foundation of Korea

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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