In Vitro Activities of Linezolid, Meropenem, and Quinupristin-Dalfopristin against Group C and G Streptococci, Including Vancomycin-Tolerant Isolates

Author:

Zaoutis Theoklis1,Moore Lynn Steele2,Furness Kathleen2,Klein Joel D.1

Affiliation:

1. Division of Pediatric Infectious Diseases, Alfred I. duPont Hospital for Children, Wilmington,1 and

2. Infectious Diseases Laboratory, Christiana Hospital, Christiana Care Health System, Newark,2 Delaware

Abstract

ABSTRACT The in vitro activities of meropenem, linezolid, quinupristin-dalfopristin, vancomycin, and penicillin against 130 clinical isolates of group C and G streptococci, including vancomycin-tolerant isolates, were evaluated. Meropenem, linezolid, quinupristin-dalfopristin, vancomycin, and penicillin MICs at which 90% of the isolates were inhibited were 0.06, 2.0, 0.25, 0.5, and ≤0.016 μg/ml, respectively. Meropenem, linezolid, quinupristin-dalfopristin, and penicillin were active against group C and G streptococci, including vancomycin-resistant strains.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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