Biochemical Mechanism of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Resistance to Stavudine-Reference-Cited by-同舟云学术

Biochemical Mechanism of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Resistance to Stavudine

Published:2001-07 Issue:7 Volume:45 Page:2144-2146
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lennerstrand Johan¹,Stammers David K.²,Larder Brendan A.¹

Affiliation:

1. Virco UK, Ltd, Cambridge CB4 0GA,1 and

2. Structural Biology Division, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN,2 United Kingdom

Abstract

ABSTRACT We have found a close correlation between viral stavudine (d4T) resistance and resistance to d4T-triphosphate at the human immunodeficiency virus type 1 reverse transcriptase (RT) level. RT from site-directed mutants with 69S-XX codon insertions and/or conventional zidovudine resistance mutations seems to be involved in an ATP-dependent resistance mechanism analogous to pyrophosphorolysis, whereas the mechanism for RT with the Q151M or V75T mutation appears to be independent of added ATP for reducing binding to d4T-triphosphate.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.7.2144-2146.2001

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