The Role of mprF Mutations in Seesaw Effect of Daptomycin-Resistant Methicillin-Resistant Staphylococcus aureus Isolates-Reference-Cited by-同舟云学术

The Role of mprF Mutations in Seesaw Effect of Daptomycin-Resistant Methicillin-Resistant Staphylococcus aureus Isolates

Published:2022-01-18 Issue:1 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Jiang Shengnan¹²,Zhuang Hemu¹²,Zhu Feiteng¹²,Wei Xiang²³,Zhang Junxiong¹⁴,Sun Lu¹²,Ji Shujuan¹²,Wang Haiping¹²,Wu Dandan⁵,Zhao Feng⁶,Yan Rushuang¹²,Yu Yunsong¹²,Chen Yan¹²^ORCID

Affiliation:

1. Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China

2. Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, China

3. Department of Respiratory Medicine, Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, China

4. Department of Clinical Laboratory, Yuhang Traditional Chinese Medicine Hospital, Hangzhou, China

5. Department of Infectious Diseases, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China

6. Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China

Abstract

The emergence of daptomycin-resistant (DAP-R) Staphylococcus aureus strains has become a global problem. Point mutations in mprF are the main cause of daptomycin (DAP) treatment failure.

Funder

NSF | NSFC-Zhejiang Joint Fund | 浙江省科学技术厅 | Natural Science Foundation of Zhejiang Province

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01295-21

Reference41 articles.

1. Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology

2. Staphylococcus aureus : superbug, super genome?