In Vitro Antiviral Activity of Cabotegravir against HIV-2-Reference-Cited by-同舟云学术

In Vitro Antiviral Activity of Cabotegravir against HIV-2

Published:2018-10 Issue:10 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Smith Robert A.¹,Wu Vincent H.¹,Zavala Christopher G.¹,Raugi Dana N.¹,Ba Selly²,Seydi Moussa²,Gottlieb Geoffrey S.¹³,

Affiliation:

1. Center for Emerging and Reemerging Infectious Diseases and Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA

2. Service des Maladies Infectieuses et Tropicales, CHNU de Fann, Dakar, Senegal

3. Department of Global Health, University of Washington, Seattle, Washington, USA

Abstract

We examined the antiviral activity of the integrase inhibitor (INI) cabotegravir against HIV-2 isolates from INI-naive individuals. HIV-2 was sensitive to cabotegravir in single-cycle and spreading-infection assays, with 50% effective concentrations (EC 50 s) in the low to subnanomolar range; comparable results were obtained for HIV-1 in both assay formats.

Funder

University of Washington Royalty Research Fund

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01299-18

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