Herpes Simplex Virus 1-Induced Ferroptosis Contributes to Viral Encephalitis

Author:

Xu Xi-Qiu12,Xu Tongran3,Ji Wenting24,Wang Chong12,Ren Yujie12,Xiong Xiaobei2,Zhou Xi24ORCID,Lin Shu-Hai3,Xu Yi1,Qiu Yang2

Affiliation:

1. Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou, Guangdong, China

2. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China

3. State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China

4. School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China

Abstract

Ferroptosis is a nonapoptotic form of programmed cell death that contributes to different neurological inflammatory diseases. However, whether HSV-1 induces ferroptosis in the CNS and the role of ferroptosis in viral pathogenesis remain unclear.

Funder

National Key Research and Development Program of China

Strategic Priority Research Program of Chinese Academy of Sciences

National Natural Science Foundation of China

International Partnership Program of CAS

CAS Youth Innovation Promotion Association

The Hubei Province Natural Science Funds for Distinguished Young Scholar

The Young Top-Notch Talent Cultivation Program of Hubei Province

Fundamental Research Funds for the Central Universities

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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