Genetic Analysis of the Salmonella FliE Protein That Forms the Base of the Flagellar Axial Structure

Author:

Hendriksen Jordan J.1,Lee Hee Jung1,Bradshaw Alexander J.1,Namba Keiichi234,Chevance Fabienne F. V.1,Minamino Tohru2,Hughes Kelly T.1

Affiliation:

1. School of Biological Sciences, University of Utah, Salt Lake City, Utah, USA

2. Graduate School of Frontiers Bioscience, Osaka University, Suita, Osaka, Japan

3. RIKEN Center for Biosystems Dynamics Research and SPring-8 Center, Suita, Osaka, Japan

4. JEOL YOKOGUSHI Research Alliance Laboratories, Osaka University, Suita, Osaka, Japan

Abstract

The FliE component of the bacterial flagellum is the first protein secreted through the flagellar type III secretion system (fT3SS) that is capable of self-assembly into the growing bacterial organelle. The FliE protein plays dual roles in the assembly of the Salmonella flagellum as the final component of the flagellar type III secretion system (fT3SS) and as an adaptor protein that anchors the rod (drive shaft) of the flagellar motor to the membrane-imbedded MS-ring structure.

Funder

HHS | NIH | National Institute of General Medical Sciences

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Reference35 articles.

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5. Macnab RM, et al. 1996. Flagella and motility, p 123–145. In Neidhardt FC, Curtiss R,III, Ingraham JL, Lin ECC, Low KB, Magasanik B, Reznikoff WS, Riley M, Schaechter M, Umbarger HE (ed), Escherichia coli and Salmonella typhimurium: cellular and molecular biology, 2nd ed. American Society for Microbiology, Washington, DC.

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