Accessing the Variability of Multicopy Genes in Complex Genomes using Unassembled Next-Generation Sequencing Reads: The Case of Trypanosoma cruzi Multigene Families-Reference-Cited by-同舟云学术

Accessing the Variability of Multicopy Genes in Complex Genomes using Unassembled Next-Generation Sequencing Reads: The Case of Trypanosoma cruzi Multigene Families

Published:2022-12-20 Issue:6 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Reis-Cunha João Luís¹²,Coqueiro-dos-Santos Anderson¹,Pimenta-Carvalho Samuel Alexandre¹,Marques Larissa Pinheiro¹,Rodrigues-Luiz Gabriela F.³,Baptista Rodrigo P.⁴⁵,Almeida Laila Viana de¹,Honorato Nathan Ravi Medeiros¹,Lobo Francisco Pereira⁶,Fraga Vanessa Gomes¹,Galvão Lucia Maria da Cunha¹⁷,Bueno Lilian Lacerda¹,Fujiwara Ricardo Toshio¹,Cardoso Mariana Santos¹,Cerqueira Gustavo Coutinho⁸,Bartholomeu Daniella C.¹^ORCID

Affiliation:

1. Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

2. Department of Biology, University of York, York, Yorkshire, United Kingdom

3. Experimental Medicine Research Cluster (EMRC), University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

4. Center for Tropical and Emerging Global Diseases and Institute of Bioinformatics, The University of Georgia, Athens, Georgia, USA

5. Houston Methodist Research Institute, Houston, Texas, USA

6. Departamento de Genética e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

7. Universidade Federal do Rio Grande do Norte, Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências Farmacêuticas, Natal, RN, Brasil

8. Personal Genome Diagnostics, Baltimore, Maryland, USA

Abstract

Sequences that have several copies in a genome, such as multicopy-gene families, mobile elements, and microsatellites, are among the most challenging genomic segments to study. They are frequently underestimated in genome assemblies, hampering the correct assessment of these important players in genome evolution and adaptation.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado de Minas Gerais

UFMG | Pró-Reitoria de Pesquisa, Universidade Federal de Minas Gerais

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02319-22

Reference52 articles.