Inflammasome Activation Dampens Type I IFN Signaling to Strengthen Anti- <i>Toxoplasma</i> Immunity-Reference-Cited by-同舟云学术

Inflammasome Activation Dampens Type I IFN Signaling to Strengthen Anti- Toxoplasma Immunity

Published:2022-12-20 Issue:6 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Hu Zhiqiang¹,Wu Dan¹,Lu Jiansen¹²,Zhang Yufen¹,Yu Shao-Meng³,Xie Yingchao¹,Li Hongyu¹,Yang Jianwu¹,Lai De-Hua³,Zeng Ke¹,Jiang Huaji¹⁴,Lun Zhao-Rong³,Yu Xiao¹²⁵^ORCID

Affiliation:

1. Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China

2. Department of Joint Surgery, Fifth Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China

3. State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China

4. Department of Orthopedics, Yue Bei People's Hospital Affiliated to Medical College of Shantou University, Shaoguan, Guangdong, China

5. Guangdong Provincial Key Lab of Single Cell Technology and Application, Southern Medical University, Guangzhou, Guangdong, China

Abstract

As a key component of innate immunity, inflammasome is critical for host antitoxoplasmosis immunity, but the underlying mechanisms are still elusive. In this study, we found that inflammasome signaling was activated by PAMPs of T. gondii , which generated a protective immunity against T. gondii invasion by suppressing type I interferon (IFN-I) production. Mechanically, inflammasome-coupled IL-1β signaling triggered the expression of negative regulator SOCS1, which bound to IRF3 to inhibit IFN-I production.

Funder

National Natural Science Foundation of China

Guangdong Basic and Applied Bais Research Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02361-22

Reference90 articles.

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