Probiotic Yeasts Inhibit Virulence of Non -albicans Candida Species

Abstract

Non- albicans Candida -associated infections have emerged as a major risk factor in the hospitalized and immunecompromised patients. Besides, antifungal-associated complications occur more frequently with these non- albicans Candida species than with C. albicans . Therefore, as an alternative approach to combat these widespread non- albicans Candida -associated infections, here we showed the probiotic effect of two yeasts, Saccharomyces cerevisiae (strain KTP) and Issatchenkia occidentalis (ApC), in preventing adhesion and biofilm formation of five non- albicans Candida strains, Candida tropicalis , Candida krusei , Candida glabrata , Candida parapsilosis , and Candida auris . The result would influence the current trend of the conversion of conventional antimicrobial therapy into beneficial probiotic microbe-associated antimicrobial treatment.