Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between Plasmodium vivax PvDBP and Plasmodium falciparum VAR2CSA-Reference-Cited by-同舟云学术

Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between Plasmodium vivax PvDBP and Plasmodium falciparum VAR2CSA

Published:2019-10-29 Issue:5 Volume:10 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Mitran Catherine J.¹^ORCID,Mena Angie¹,Gnidehou Sedami²,Banman Shanna¹,Arango Eliana³,Lima Barbara A. S.⁴,Lugo Hazel¹,Ganesan Aravindhan⁵,Salanti Ali⁶,Mbonye Anthony K.⁷,Ntumngia Francis⁸^ORCID,Barakat Khaled⁵,Adams John H.⁸,Kano Flora S.⁴,Carvalho Luzia H.⁴,Maestre Amanda E.³,Good Michael F.⁹¹⁰,Yanow Stephanie K.¹¹⁰

Affiliation:

1. School of Public Health, University of Alberta, Edmonton, Alberta, Canada

2. Department of Biology, Campus Saint-Jean University of Alberta, Edmonton, Alberta, Canada

3. Grupo Salud y Comunidad, Facultad de Medicina, Medellín, Antioquia, Colombia

4. Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil

5. Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada

6. Department of Immunology and Microbiology, Centre for Medical Parasitology, University of Copenhagen, Copenhagen, Denmark

7. School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda

8. College of Public Health, University of South Florida, Tampa, Florida, USA

9. Institute for Glycomics, Griffith University, Southport, Queensland, Australia

10. Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada

Abstract

In this work, we describe a molecular mechanism of heterologous immunity between two distant species of Plasmodium . Our results suggest a mechanism that subverts the classic parasite strategy of presenting highly polymorphic epitopes in surface antigens to evade immunity to that parasite. This alternative immune pathway can be exploited to protect pregnant women from falciparum placental malaria by designing vaccines to cryptic epitopes that elicit broadly inhibitory antibodies against variant parasite strains.

Funder

Li Ka Shing Institute of Virology

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02343-19

Reference78 articles.

1. Effectiveness of a group B outer membrane vesicle meningococcal vaccine against gonorrhoea in New Zealand: a retrospective case-control study