Affiliation:
1. Roche Institute of Molecular Biology, Nutley, New Jersey 07110
Abstract
Poxvirus strains differ with respect to the effect of rifampicin on viral protein synthesis. Rifampicin severely depressed vaccinia-directed protein synthesis but had little effect on the rate of cowpox-directed protein synthesis, including one late virus-induced enzyme. The spectrum of polypeptides synthesized in cowpox-infected cells was similar in the presence or absence of rifampicin except for one significant difference. After removal of rifampicin, viruslike particles assembled to some extent, even when protein synthesis was inhibited by cycloheximide. However, reversal was more extensive if protein synthesis was allowed.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Reference14 articles.
1. Rifampicin and poxvirus replication;Ben-Ishai V.;Nature (London),1969
2. Selective Inhibition of vaccinia virus by the antibiotic rifampicin;Heller E.;Nature (London),1969
3. Rifampicin inhibition of vaccinia replication;McAuslan B. R.;Biochem. Biophys. Res. Conimun.,1969
4. MeAuslan B. R. 1969. The biochemistry of poxvirus replication p. 361-413. In H. B. Levy (ed.) The biochemistry of viruses. Marcel Dekker Inc. New York.
5. Stimulation of the thymidine phosphorylating system in Hela cells in infection with poxvirus;McAuslan B. R.;Biochem. Biophys. Res. Commun.,1962
Cited by
28 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献