In Vitro Pharmacodynamics of Fosfomycin against Carbapenem-Resistant Enterobacter cloacae and Klebsiella aerogenes-Reference-Cited by-同舟云学术

In Vitro Pharmacodynamics of Fosfomycin against Carbapenem-Resistant Enterobacter cloacae and Klebsiella aerogenes

Published:2020-08-20 Issue:9 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lim Tze-Peng¹²³^ORCID,Teo Jocelyn Qi-Min¹⁴^ORCID,Goh Audrey Wei-Ling⁵,Tan Si-Xuan¹,Koh Tse-Hsien⁶³,Lee Winnie Hui-Ling¹,Cai Yiying¹⁵,Tan Thuan-Tong⁷²,Kwa Andrea Lay-Hoon¹²⁸^ORCID

Affiliation:

1. Department of Pharmacy, Singapore General Hopsital, Singapore

2. SingHealth Duke-NUS, Medicine Academic Clinical Programme, Singapore

3. SingHealth Duke-NUS, Pathology Academic Clinical Programme, Singapore

4. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore

5. Department of Pharmacy, National University of Singapore, Singapore

6. Department of Microbiology, Singapore General Hopsital, Singapore

7. Department of Infectious Diseases, Singapore General Hopsital, Singapore

8. Emerging Infectious Diseases Program, Duke-NUS Medical School, Singapore

Abstract

The increase of carbapenem-resistant Enterobacterales (CRE) and lack of therapeutic options due to the scarcity of new antibiotics has sparked interest toward the use of intravenous fosfomycin against systemic CRE infections. We aimed to investigate the in vitro pharmacodynamics of fosfomycin against carbapenem-resistant Enterobacter cloacae and Klebsiella aerogenes . Time-kill studies and population analysis profiles were performed with eight clinical CRE isolates, which were exposed to fosfomycin concentrations ranging from 0.

Funder

MOH | National Medical Research Council

Singapore General Hospital

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00536-20

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