Impact of antibiotic pharmacokinetics in urine on recurrent bacteriuria following treatment of complicated urinary tract infections-Reference-Cited by-同舟云学术

Impact of antibiotic pharmacokinetics in urine on recurrent bacteriuria following treatment of complicated urinary tract infections

Published:2023-10-18 Issue:10 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Melnick David¹^ORCID,Talley Angela K.¹,Gupta Vipul K.¹,Critchley Ian A.¹,Eckburg Paul B.¹,Hamed Kamal A.¹^ORCID,Bhatt Nivedita¹,Moore Gary²,Austin Daren³,Rubino Christopher M.⁴,Bhavnani Sujata M.⁴,Ambrose Paul G.⁴

Affiliation:

1. Spero Therapeutics, Inc. , Cambridge, Massachusetts, USA

2. Moore Computing Services, Inc. , Little Rock, Arkansas, USA

3. GlaxoSmithKline , London, UK

4. Institute for Clinical Pharmacodynamics, Inc. , Schenectady, New York, USA

Abstract

ABSTRACT The clinical relevance of bacteriuria following antibiotic treatment of complicated urinary tract infections in clinical trials remains controversial. We evaluated the impact of urine pharmacokinetics on the timing of recurrent bacteriuria in a recently completed trial that compared oral tebipenem pivoxil hydrobromide to intravenous ertapenem. The urinary clearance and urine dwell time of ertapenem were prolonged relative to tebipenem and were associated with a temporal difference in the repopulation of bladder urine with bacteria following treatment, potentially confounding the assessment of efficacy.

Funder

Spero Therapeutics

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00535-23

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