Genetic Mutations Associated with Isoniazid Resistance in Mycobacterium tuberculosis in Mongolia

Author:

Narmandakh Erdenegerel1,Tumenbayar Oyuntuya1,Borolzoi Tsetsegtuya1,Erkhembayar Baasansuren1,Boldoo Tsolmon1,Dambaa Naranzul1,Burneebaatar Buyankhishig1,Nymadawa Naranbat2,Mitarai Satoshi3,Jav Sarantuya4,Chiang Chen-Yuan567

Affiliation:

1. National Center for Communicable Diseases, Ulaanbaatar, Mongolia

2. Mongolian Anti-Tuberculosis Coalition, Ulaanbaatar, Mongolia

3. Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan

4. Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia

5. International Union against Tuberculosis and Lung Diseases, Paris, France

6. Division of Pulmonary Medicine, Department of Internal Medicine, Wanfang Hospital, Taipei Medical University, Taipei, Taiwan

7. Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

Abstract

Globally, mutations in the katG gene account for the majority of isoniazid-resistant strains of Mycobacterium tuberculosis . Buyankhishig et al. analyzed a limited number of Mycobacterium tuberculosis strains in Mongolia and found that isoniazid resistance was mainly attributable to inhA mutations (B. Buyankhishig, T. Oyuntuya, B. Tserelmaa, J. Sarantuya, et al., Int J Mycobacteriol 1:40–44, 2012, https://doi.org/10.1016/j.ijmyco.2012.01.007 ).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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