Germ Line Deletion Reveals a Nonessential Role of Atypical Mitogen-Activated Protein Kinase 6/Extracellular Signal-Regulated Kinase 3-Reference-Cited by-同舟云学术

Germ Line Deletion Reveals a Nonessential Role of Atypical Mitogen-Activated Protein Kinase 6/Extracellular Signal-Regulated Kinase 3

Published:2019-03-15 Issue:6 Volume:39 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Ronkina N.¹,Schuster-Gossler K.²,Hansmann F.³,Kunze-Schumacher H.⁴,Sandrock I.⁵,Yakovleva T.¹,Lafera J.¹,Baumgärtner W.³,Krueger A.⁴,Prinz I.⁵,Gossler A.²,Kotlyarov A.¹,Gaestel M.¹

Affiliation:

1. Institute of Cell Biochemistry, Hannover Medical School, Hannover, Germany

2. Institute of Molecular Biology, Hannover Medical School, Hannover, Germany

3. University of Veterinary Medicine Hannover, Department of Pathology, Hannover, Germany

4. Institute of Molecular Medicine, Goethe University Frankfurt am Main, Frankfurt am Main, Germany

5. Institute of Immunology, Hannover Medical School, Hannover, Germany

Abstract

Mitogen-activated protein kinase 6/extracellular signal-regulated kinase 3 (MAPK6/ERK3) is an atypical member of the MAPKs. An essential role has been suggested by the perinatal lethal phenotype of ERK3 knockout mice carrying a lacZ insertion in exon 2 due to pulmonary dysfunction and by defects in function, activation, and positive selection of T cells.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00516-18

Reference34 articles.

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