Genome-Wide Analysis Unveils DNA Helicase RECQ1 as a Regulator of Estrogen Response Pathway in Breast Cancer Cells-Reference-Cited by-同舟云学术

Genome-Wide Analysis Unveils DNA Helicase RECQ1 as a Regulator of Estrogen Response Pathway in Breast Cancer Cells

Published:2021-03-24 Issue:4 Volume:41 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Lu Xing¹,Redon Christophe E.²,Tang Wei³,Parvathaneni Swetha¹,Bokhari Bayan¹⁴,Debnath Subrata¹,Li Xiao Ling⁵,Muys Bruna R.⁵,Song Young⁶,Pongor Lorinc S.²,Sheikh Omar⁷,Green Andrew R.⁷,Madhusudan Srinivasan⁷,Lal Ashish⁵^ORCID,Ambs Stefan³,Khan Javed⁶,Aladjem Mirit I.²,Sharma Sudha¹⁸^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology, College of Medicine, Howard University, Washington, DC, USA

2. Developmental Therapeutics Branch, Laboratory of Molecular Pharmacology, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA

3. Molecular Epidemiology Section, Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, Maryland, USA

4. Department of Biochemistry, Faculty of Applied Medical Science, Umm Al-Qura University, Makkah, Saudi Arabia

5. Regulatory RNAs and Cancer Section, Genetics Branch, CCR, NCI, NIH, Bethesda, Maryland, USA

6. Oncogenomics Section, Genetics Branch, CCR, NCI, NIH, Bethesda, Maryland, USA

7. Division of Cancer and Stem Cells, Nottingham Breast Cancer Research Centre, University of Nottingham Biodiscovery Institute, Nottingham University Hospitals, Nottingham, United Kingdom

8. National Human Genome Center, Howard University College of Medicine, Washington, DC

Abstract

Susceptibility to breast cancer is significantly increased in individuals with germ line mutations in RECQ1 (also known as RECQL or RECQL1 ), a gene encoding a DNA helicase essential for genome maintenance. We previously reported that RECQ1 expression predicts clinical outcomes for sporadic breast cancer patients stratified by estrogen receptor (ER) status.

Funder

National Science Foundation

HHS | NIH | National Institute of General Medical Sciences

HHS | NIH | National Institute on Aging

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00515-20

Reference68 articles.

1. RECQL, a Member of the RecQ Family of DNA Helicases, Suppresses Chromosomal Instability