Assay of fluconazole by megabore capillary gas-liquid chromatography with nitrogen-selective detection

Author:

Harris S C1,Wallace J E1,Foulds G1,Rinaldi M G1

Affiliation:

1. Laboratory Service, Audie L. Murphy Memorial Veterans' Hospital, San Antonio, Texas.

Abstract

A megabore column gas-liquid chromatographic method which uses nitrogen-phosphorus detection was developed for the analysis of fluconazole in plasma, serum, cerebrospinal fluid, or urine. The assay was linear from 0.2 to 200 micrograms/ml and had an average coefficient of variation of 7%. The suitability of the assay for pharmacokinetic studies was demonstrated.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference5 articles.

1. Fluconazole penetration into cerebrospinal fluid: implications for treating fungal infections of the central nervous system;Arndt C. A. S.;J. Infect. Dis.,1988

2. Debruyne D. J. P. Ryckelynck M. C. Bigot and M. Moulin. 1988. Determination of fluconazole in biological fluids by capil

3. Fluconazole penetration into cerebrospinal fluid in humans;Foulds G.;J. Clin. Pharmacol.,1988

4. Pharmacokinetic evaluation of UK-49,858, a metabolically stable triazole antifungal drug, in animals and humans;Humphrey M. J.;Antimicrob. Agents Chemother.,1985

5. Gas chromatographic method for the determination of fluconazole, a novel antifungal agent in human plasma and urine;Wood P. R.;J. Chromatogr.,1986

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3