Affiliation:
1. Squibb Institute for Medical Research, Princeton, New Jersey 08540
Abstract
The increased clinical use of broad-spectrum antibiotics, immunosuppressives, and anti-inflammatory agents is thought to have contributed to the increased incidence of renal infections due to
Candida albicans
. To aid in the search for improved anticandidal agents, we developed an experimental model in which
C. albicans
is injected into the medulla of the surgically exposed kidney of the rat. The ensuing infection is restricted to the urinary tract and can be treated successfully with amphotericin B. This model promises to be of merit in the evaluation of agents potentially useful in treating candidiasis of the urinary tract.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference13 articles.
1. Organisms encountered in urine cultures over a 10- year period;Blazevic D. J.;Appl. Microbiol.,1972
2. Garrod L. P. and F. O'Grady (ed.). 1971. Antibiotics and chemotherapy. The Williams & Wilkins Co. Baltimore.
3. Urinary tract infections caused by yeasts;Hantschke D.;Mykosen,1970
4. Renal candidiasis. A cause of anuria;Harbach L. G.;Brit. J. Urol.,1970
5. Experimental ascending candida infection in urinary ways;Hatala M.;Cas. Lek. Cesk.,1971
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献