In Vitro Activities of Moxifloxacin and Other Fluoroquinolones against Mycoplasma pneumoniae

Author:

Hamamoto Kumiko1,Shimizu Takashi1,Fujimoto Naoyuki1,Zhang Ye1,Arai Sumio1

Affiliation:

1. Department of Bacteriology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan

Abstract

ABSTRACT A total of 105 isolates of Mycoplasma pneumoniae were evaluated for susceptibility to moxifloxacin, sparfloxacin, levofloxacin, and ciprofloxacin. Moxifloxacin, a newly synthesized compound, showed the greatest activity. The MICs and MBCs at which 50 and 90% of isolates were affected were 0.15 (MIC 50 and MBC 50 ) and 0.3 μg/ml (MIC 90 and MBC 90 ) respectively. The results indicate that moxifloxacin might be promising an antimycoplasmal agent.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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