Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates-Reference-Cited by-同舟云学术

Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates

Published:2023-01-31 Issue:1 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Matsumoto Kaho¹²^ORCID,Kuwata Takeo¹,Tolbert William D.³,Richard Jonathan⁴⁵,Ding Shilei⁴⁵,Prévost Jérémie⁴⁵,Takahama Shokichi⁶,Judicate George P.¹,Ueno Takamasa¹^ORCID,Nakata Hirotomo⁷,Kobayakawa Takuya⁸,Tsuji Kohei⁸,Tamamura Hirokazu⁸,Smith Amos B.⁹,Pazgier Marzena³^ORCID,Finzi Andrés⁴⁵^ORCID,Matsushita Shuzo¹^ORCID

Affiliation:

1. Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan

2. Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

3. Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

4. Centre de Recherche du CHUM (CRCHUM), Montreal, Quebec, Canada

5. Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université de Montréal, Montreal, Quebec, Canada

6. Laboratory of Immunosenescence, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan

7. Department of Hematology, Rheumatology, and Infectious Diseases, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

8. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan

9. Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Abstract

Small CD4-mimetic compound (CD4mc) interacts with the Phe43 cavity and triggers conformational changes, enhancing antibody-mediated neutralization and antibody-dependent cellular cytotoxicity (ADCC). Here, we evaluated the effect of YIR-821, a novel CD4mc, against clinical isolates, including both subtype B and non-B subtype viruses.

Funder

MEXT | JST | Support Program for Starting up Innovation Hub

MEXT | Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

Canadian Institute of Health Research Foundation

Foundation for the National Institutes of Health

HHS | NIH | National Institute of Allergy and Infectious Diseases

Canadian Research Chair for Retroviral Entry

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology