Affiliation:
1. Mycoplasma Laboratory, Statens Seruminstitut, Copenhagen S., Denmark.
Abstract
Antibodies to the mitotic spindle apparatus (MS) have been detected in only a very few patient sera studied for antinuclear antibodies by routine screening (G. A. McCarty, D. W. Velencia, and M. J. Fritzler, J. Rheumatol. 11:213-218, 1984). We found anti-MS antibodies to be quite common in sera from patients with Mycoplasma pneumoniae, especially in those who developed cold agglutinins (71%). Absorption experiments indicated that the formation of anti-MS antibodies is not triggered by epitopes on the M. pneumoniae surface. These antibodies were distinct from cold agglutinins, antibrain antibodies, and smooth-muscle antibodies. All patients previously reported to harbor anti-MS had clinical features compatible with a diagnosis of systemic lupus erythematosus, rheumatoid arthritis, or an evolving connective-tissue disorder. Such systemic disorders might develop in a small proportion of patients who have had M. pneumoniae illness.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference7 articles.
1. Biberfeld G. 1985. Infection sequelae and autoimmnune reactions in Mycoplasma pneumoniae infection p. 293-311. In S. Razin and M. F. Barile (ed.) The mycoplasmas vol. IV. Academic Press Inc. New York.
2. Smooth muscle antibodies in Mycoplasma pneumoniae infection;Biberfeld G.;Clin. Exp. Immunol.,1976
3. IgM autoantibody to intermediate filaments in Mycoplasma pneumoniae infections;Bretherton L.;Clin. Immunol. Immunopathol.,1981
4. Manifestations and complications of Mycoplasma pneumoniae disease: a review;Lind K.;Yale J. Biol. Med. .,1983
5. Antibody to the mitotic spindle apparatus: immunologic characteristics and cytologic studies;McCarty G. A.;J. Rheumatol.,1984
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