Affiliation:
1. Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032
Abstract
Exposure of
Escherichia coli
to critical acridine orange (AO) concentrations did not result in loss of viability. However, the deoxyribonucleic acid (DNA) of cells exposed to such agents was rapidly degraded and repolymerized. On the other hand, a bacterium deficient in DNA repair (
pol A
1
−
, lacking DNA polymerase) was sensitive to the action of AO. The DNA of such cells was also degraded but it was not repaired.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
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