Listeria monocytogenes TcyKLMN Cystine/Cysteine Transporter Facilitates Glutathione Synthesis and Virulence Gene Expression

Author:

Brenner Moran1,Friedman Sivan1,Haber Adi2,Livnat-Levanon Nurit2,Borovok Ilya1,Sigal Nadejda1,Lewinson Oded2,Herskovits Anat A.1ORCID

Affiliation:

1. The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

2. Department of Biochemistry, The Bruce and Ruth Rappaport Faculty of Medicine, The Rappaport Institute for Biomedical research, Technion—Israel Institute of Technology, Haifa, Israel

Abstract

Bacterial pathogens sense the repertoire of metabolites in the mammalian niche and use this information to shift into the pathogenic state to accomplish a successful infection. Glutathione is a virulence-activating signal that is synthesized by L. monocytogenes during infection of mammalian cells.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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