Mycobacterium tuberculosis-Specific CD4 T Cells Expressing Transcription Factors T-Bet or RORγT Associate with Bacterial Control in Granulomas-Reference-Cited by-同舟云学术

Mycobacterium tuberculosis-Specific CD4 T Cells Expressing Transcription Factors T-Bet or RORγT Associate with Bacterial Control in Granulomas

Published:2023-06-27 Issue:3 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Grant Nicole L.¹,Kelly Kristen²,Maiello Pauline²³,Abbott Helena²,O’Connor Shelby⁴^ORCID,Lin Philana Ling⁵³,Scanga Charles A.²³^ORCID,Flynn JoAnne L.²³^ORCID

Affiliation:

1. Department of Infectious Disease and Microbiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA

2. Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

3. Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

4. Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison Wisconsin, USA

5. Department of Pediatrics, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

Abstract

Tuberculosis, caused by the bacterial pathogen Mycobacterium tuberculosis , kills 1.5 million people each year, despite the existence of effective drugs and a vaccine that is given to infants in most countries. Clearly, we need better vaccines against this disease.

Funder

Bill and Melinda Gates Foundation

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00477-23

Reference73 articles.

1. Identification of Secreted Proteins of Mycobacterium tuberculosis by a Bioinformatic Approach

2. The TB-specific CD4+ T cell immune repertoire in both cynomolgus and rhesus macaques largely overlap with humans