Maternal Bacterial Engraftment in Multiple Body Sites of Cesarean Section Born Neonates after Vaginal Seeding—a Randomized Controlled Trial

Author:

Mueller Noel T.12,Differding Moira K.12,Sun Haipeng3,Wang Jincheng3,Levy Shira45,Deopujari Varsha5,Appel Lawrence J.12,Blaser Martin J.6ORCID,Kundu Tanima6,Shah Ankit A.7,Dominguez Bello Maria Gloria348910ORCID,Hourigan Suchitra K.45

Affiliation:

1. Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA

2. Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, Maryland, USA

3. Department of Biochemistry and Microbiology, Rutgers University, New Brunswick, New Jersey, USA

4. Clinical Microbiome Unit (CMU), Laboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

5. Inova Children’s Hospital, Inova Health System, Falls Church, Virginia, USA

6. Center for Advanced Biotechnology and Medicine, Rutgers University, New Brunswick, New Jersey, USA

7. Inova Women’s Hospital, Inova Health System, Falls Church, Virginia, USA

8. Department of Anthropology, Rutgers University, New Brunswick, New Jersey, USA

9. Institute for Food, Nutrition and Health, Rutgers University, New Brunswick, New Jersey, USA

10. Canadian Institute for Advanced Research (CIFAR), Toronto, Ontario, Canada

Abstract

Children delivered by elective C-section are not exposed to the birth canal and show altered microbiota development. Impairing microbial colonization during early life alters metabolic and immune programming and is associated with an increased risk of immune and metabolic diseases.

Funder

HHS | NIH | NIH Clinical Center

JHU | Johns Hopkins Bloomberg School of Public Health

Rutgers, The State University of New Jersey

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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