Viral Mimicry of Interleukin-17A by SARS-CoV-2 ORF8-Reference-Cited by-同舟云学术

Viral Mimicry of Interleukin-17A by SARS-CoV-2 ORF8

Published:2022-04-26 Issue:2 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Wu Xin¹,Xia Tian¹,Shin Woo-Jin¹²,Yu Kwang-Min³,Jung Wooram¹,Herrmann Alexandra⁴,Foo Suan-Sin¹,Chen Weiqiang¹^ORCID,Zhang Pengfei¹,Lee Jong-Soo⁵,Poo Haryoung⁶,Comhair Suzy A. A.⁷,Jehi Lara⁸,Choi Young Ki³^ORCID,Ensser Armin⁴^ORCID,Jung Jae U.¹^ORCID

Affiliation:

1. Cancer Biology Department, Infection Biology Program, and Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

2. Cleveland Clinic Florida Research & Innovation Center, Port St. Lucie, Florida, USA

3. Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea

4. Institute for Clinical and Molecular Virology, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany

5. College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea

6. Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea

7. Respiratory Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

8. Department of Neurology, Epilepsy Center, Cleveland Clinic, Cleveland, Ohio, USA

Abstract

Patients infected with SARS-CoV-2 variants lacking open reading frame 8 (ORF8) have been associated with milder infection and disease outcome, but the molecular mechanism behind how this viral accessory protein mediates disease pathogenesis is not yet known. In our study, we revealed that secreted ORF8 protein mimics host IL-17 to activate IL-17 receptors A and C (IL-17RA/C) and induces a significantly stronger inflammatory response than host IL-17A, providing molecular insights into the role of ORF8 in COVID-19 pathogenesis and serving as a potential therapeutic target.

Funder

KRIBB, Korea

The institute for Basic science, Korea

Bayerisches Staatsministerium für Bildung und Kultus, Wissenschaft und Kunst

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00402-22

Reference59 articles.

1. Cascella M Rajnik M Aleem A Dulebohn S Di Napoli R. 2021. Features evaluation and treatment of coronavirus (COVID-19). StatPearls https://www.statpearls.com/articlelibrary/viewarticle/52171/.

2. A new coronavirus associated with human respiratory disease in China

3. Cytokine Storm

4. A pneumonia outbreak associated with a new coronavirus of probable bat origin

5. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene;Rouvier E;J Immunol,1993

Cited by 45 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Produção de anticorpos e citocinas em resposta ao SARS-CoV-2: comparação entre imunidade vacinal e híbrida;Revista do Instituto Adolfo Lutz;2024-06-24

2. SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progression;PLOS Pathogens;2024-05-23

3. Comprehensive genomic analysis of the SARS-CoV-2 Omicron variant BA.2.76 in Jining City, China, 2022;BMC Genomics;2024-04-17

4. Positive selection underlies repeated knockout of ORF8 in SARS-CoV-2 evolution;Nature Communications;2024-04-13

5. Mechanistic insights into bone remodelling dysregulation by human viral pathogens;Nature Microbiology;2024-02-05