Evolution of Immune Evasion and Host Range Expansion by the SARS-CoV-2 B.1.1.529 (Omicron) Variant-Reference-Cited by-同舟云学术

Evolution of Immune Evasion and Host Range Expansion by the SARS-CoV-2 B.1.1.529 (Omicron) Variant

Published:2023-04-25 Issue:2 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Ren Wenlin¹,Zhang Yu¹,Rao Juhong²³,Wang Ziyi⁴,Lan Jun⁴,Liu Kunpeng²³,Zhang Xuekai²³,Hu Xue²,Yang Chen¹,Zhong Guocai⁵⁶^ORCID,Zhang Rong⁷,Wang Xinquan⁴,Shan Chao²,Ding Qiang¹^ORCID

Affiliation:

1. Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China

2. State Key Laboratory of Virology, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China

3. University of Chinese Academy of Sciences, Beijing, China

4. School of Life Sciences, Tsinghua University, Beijing, China

5. Shenzhen Bay Laboratory, Shenzhen, China

6. School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China

7. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, China

Abstract

The recently emerged SARS-CoV-2 Omicron variant with numerous mutations in the spike protein has rapidly become the dominant strain, thereby raising concerns about the effectiveness of vaccines. Here, we found that the Omicron variant exhibits a reduced sensitivity to serum neutralizing activity induced by a three-dose inactivated vaccine but remains sensitive to entry inhibitors or an ACE2-Ig decoy receptor.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00416-23

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