Cystic Fibrosis Rapid Response: Translating Multi-omics Data into Clinically Relevant Information-Reference-Cited by-同舟云学术

Cystic Fibrosis Rapid Response: Translating Multi-omics Data into Clinically Relevant Information

Published:2019-04-30 Issue:2 Volume:10 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Cobián Güemes Ana Georgina¹²,Lim Yan Wei¹²,Quinn Robert A.³,Conrad Douglas J.⁴,Benler Sean¹²,Maughan Heather⁵⁶,Edwards Rob²⁷,Brettin Thomas⁸,Cantú Vito Adrian²⁷,Cuevas Daniel²⁷,Hamidi Rohaum⁴,Dorrestein Pieter³,Rohwer Forest¹²

Affiliation:

1. Department of Biology, San Diego State University, San Diego, California, USA

2. Viral Information Institute at San Diego State University, San Diego, California, USA

3. Skaggs School of Pharmacy, University of California San Diego, La Jolla, California, USA

4. Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, La Jolla, California, USA

5. Ronin Institute, Montclair, New Jersey, USA

6. Wholon, San Diego, California, USA

7. Computational Sciences Research Center, San Diego State University, San Diego, California, USA

8. Argonne National Laboratory, Argonne, Illinois, USA

Abstract

Proper management of polymicrobial infections in patients with cystic fibrosis (CF) has extended their life span. Information about the composition and dynamics of each patient’s microbial community aids in the selection of appropriate treatment of pulmonary exacerbations. We propose the cystic fibrosis rapid response (CFRR) as a fast approach to determine viral and microbial community composition and activity during CF pulmonary exacerbations. The CFRR potential is illustrated with a case study in which a cystic fibrosis fatal exacerbation was characterized by the presence of shigatoxigenic Escherichia coli . The incorporation of the CFRR within the CF clinic could increase the life span and quality of life of CF patients.

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00431-19

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