Adenosine Awakens Metabolism to Enhance Growth-Independent Killing of Tolerant and Persister Bacteria across Multiple Classes of Antibiotics-Reference-Cited by-同舟云学术

Adenosine Awakens Metabolism to Enhance Growth-Independent Killing of Tolerant and Persister Bacteria across Multiple Classes of Antibiotics

Published:2022-06-28 Issue:3 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Kitzenberg David A.¹²,Lee J. Scott²,Mills Krista B.³^ORCID,Kim Ju-Sim³^ORCID,Liu Lin³,Vázquez-Torres Andrés¹³^ORCID,Colgan Sean P.¹²⁴³,Kao Daniel J.²⁴

Affiliation:

1. Molecular Biology Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA

2. Mucosal Inflammation Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA

3. Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA

4. Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA

Abstract

Antibiotic tolerance, which is a hallmark of persister bacteria, contributes to treatment-refractory infections and the emergence of heritable antimicrobial resistance. Drugs that reverse tolerance and persistence may become part of the arsenal to combat antimicrobial resistance.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Veterans Affairs

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Crohn’s and Colitis Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00480-22

Reference54 articles.