Azole Resistance in Aspergillus fumigatus Isolates from the ARTEMIS Global Surveillance Study Is Primarily Due to the TR/L98H Mutation in thecyp51AGene

Abstract

ABSTRACTWe surveyed 497 isolates ofAspergillus fumigatuscollected from 2008 to 2009 as part of the ARTEMIS global surveillance study for elevated MIC values to itraconazole, voriconazole, and posaconazole. Sequencing of thecyp51Agene revealed that 8/29 isolates with elevated MIC values to one or more triazoles, all originating in China, contained the TR/L98H mutation associated with resistant European isolates ofA. fumigatus. This is the first time the TR/L98H mutation has been identified outside Europe.