Genome Sequences of 28 Bordetella pertussis U.S. Outbreak Strains Dating from 2010 to 2012

Author:

Harvill Eric T.1,Goodfield Laura L.1,Ivanov Yury1,Meyer Jessica A.1,Newth Christopher2,Cassiday Pamela3,Tondella Maria Lucia3,Liao Patty2,Zimmerman Jerry2,Meert Kathleen2,Wessel David2,Berger John2,Dean J. Michael24,Holubkov Richard24,Burr Jeri24,Liu Teresa24,Brinkac Lauren5,Kim Maria5,Losada Liliana5

Affiliation:

1. The Pennsylvania State University, University Park, Pennsylvania, USA

2. NICHD Collaborative Pediatric Critical Care Research Network, Salt Lake City, Utah, USA

3. Centers for Disease Control and Prevention, Atlanta, Georgia, USA

4. University of Utah Data Coordinating Center, Salt Lake City, Utah, USA

5. J. Craig Venter Institute, Rockville, Maryland, USA

Abstract

ABSTRACT Despite the availability of highly effective vaccines, Bordetella pertussis incidence has been rapidly rising in highly vaccinated populations. Recent outbreaks have received media attention, feeding concerns about the emergence of dangerous new strains with increased virulence or that escape vaccine-induced immunity. To accelerate the study of this reemerging pathogen, we sequenced the genomes of 28 B. pertussis strains isolated during outbreaks from 2010 through 2012, making both strains and sequence data available to the scientific community.

Publisher

American Society for Microbiology

Subject

Genetics,Molecular Biology

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