Genome Sequences of Two Carbapenemase-Resistant Klebsiella pneumoniae ST258 Isolates

Author:

Ramirez Maria Soledad12,Xie Gang3,Johnson Shannon3,Davenport Karen3,van Duin David4,Perez Federico5,Bonomo Robert A.56,Chain Patrick3,Tolmasky Marcelo E.1

Affiliation:

1. Center for Applied Biotechnology Studies, Department of Biological Science, California State University, Fullerton, Fullerton, California, USA

2. IMPaM (UBA-CONICET), Buenos Aires, Argentina

3. Los Alamos National Laboratory, Los Alamos, New Mexico, USA

4. University of North Carolina, Chapel Hill, North Carolina, USA

5. Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA

6. Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

Abstract

ABSTRACT Klebsiella pneumoniae , an ESKAPE group ( Enterococcus faecium , Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa , and Enterobacter species) pathogen, has acquired multiple antibiotic resistance genes and is becoming a serious public health threat. Here, we report the genome sequences of two representative strains of K. pneumoniae from the emerging K. pneumoniae carbapenemase (KPC) outbreak in northeast Ohio belonging to sequence type 258 (ST258) (isolates Kb140 and Kb677, which were isolated from blood and urine, respectively). Both isolates harbor a bla KPC gene, and strain Kb140 carries bla KPC-2 , while Kb677 carries bla KPC-3 .

Publisher

American Society for Microbiology

Subject

Genetics,Molecular Biology

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