Draft Genome Sequence of Escherichia coli Strain Nissle 1917 (Serovar O6:K5:H1)-Reference-Cited by-同舟云学术

Draft Genome Sequence of Escherichia coli Strain Nissle 1917 (Serovar O6:K5:H1)

Published:2013-05-02 Issue:2 Volume:1 Page:
ISSN:2169-8287
Container-title:Genome Announcements
language:en
Short-container-title:Genome Announc

Author:

Cress Brady F.¹,Linhardt Robert J.¹²³,Koffas Mattheos A. G.¹

Affiliation:

1. Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, USA

2. Department of Chemistry, Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, USA

3. Department of Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, USA

Abstract

ABSTRACT We announce the availability of the 5.023-Mbp high-quality draft assembly of the Escherichia coli strain Nissle 1917 (serovar O6:K5:H1) genome. Short genomic segments from this important probiotic strain have been available in public databases, but the full genome sequence has remained inaccessible. Thus, high-coverage, whole genome sequencing of E. coli Nissle 1917 is presented herein. Reannotation and metabolic reconstruction will enable comparative genomics analysis and model-guided predictions of genetic manipulations leading to increased production of the K5 capsular polysaccharide known as N -acetyl heparosan, a precursor to the anticoagulant pharmaceutical heparin.

Publisher

American Society for Microbiology

Subject

Genetics,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/genomeA.00047-13

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4. Genomic peculiarity of coding sequences and metabolic potential of probiotic Escherichia coli strain Nissle 1917 inferred from raw genome data

5. Analysis of E. coli K5 capsular polysaccharide heparosan

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