Draft Genome Sequence of Streptomyces rapamycinicus Strain NRRL 5491, the Producer of the Immunosuppressant Rapamycin-Reference-Cited by-同舟云学术

Draft Genome Sequence of Streptomyces rapamycinicus Strain NRRL 5491, the Producer of the Immunosuppressant Rapamycin

Published:2013-08-29 Issue:4 Volume:1 Page:
ISSN:2169-8287
Container-title:Genome Announcements
language:en
Short-container-title:Genome Announc

Author:

Baranasic Damir¹²,Gacesa Ranko¹,Starcevic Antonio¹,Zucko Jurica¹,Blažič Marko³,Horvat Marinka³,Gjuračić Krešimir³,Fujs Štefan³,Hranueli Daslav¹,Kosec Gregor³⁴,Cullum John²,Petković Hrvoje³⁵

Affiliation:

1. Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia

2. Department of Genetics, University of Kaiserslautern, Kaiserslautern, Germany

3. Acies Bio d.o.o., Ljubljana, Slovenia

4. Centre of Excellence for Integrated Approaches in Chemistry and Biology of Proteins (CIPKeBiP), Ljubljana, Slovenia

5. Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Universidad de Cantabria, CSIC, SODERCAN, Santander, Spain

Abstract

ABSTRACT Streptomyces rapamycinicus strain NRRL 5491 produces the important drug rapamycin. It has a large genome of 12.7 Mb, of which over 3 Mb consists of 48 secondary metabolite biosynthesis clusters.

Publisher

American Society for Microbiology

Subject

Genetics,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/genomeA.00581-13

Reference14 articles.

1. Five new members of the Streptomyces violaceusniger 16S rRNA gene clade: Streptomyces castelarensis sp. nov., comb. nov., Streptomyces himastatinicus sp. nov., Streptomyces mordarskii sp. nov., Streptomyces rapamycinicus sp. nov. and Streptomyces ruanii sp. nov.

2. Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle.

3. mTOR signaling for biological control and cancer

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