Affiliation:
1. Division of Communicable Disease and Immunology, Walter Reed Army Institute of Research, Washington, D.C.
Abstract
Falkow, Stanley
(Walter Reed Army Institute of Research, Washington, D.C.)
and L. S. Baron
. Episomic element in a strain of
Salmonella typhosa
. J. Bacteriol.
84:
581–589. 1962.—An episomic element, F
0
-
lac
+
, has been identified in a strain of
Salmonella typhosa
isolated from a natural habitat. The F
0
-
lac
+
element is transferred at high frequency as a single unit of transmission and replication without linkage to any other genetic character. Cells receiving F
0
-
lac
+
are heterogenotes as if F
0
-
lac
+
is not integrated as part of the linear structure of the chromosome, but rather replicates autonomously or in some other association with the genome. Evidence from complementation tests and transduction experiments is presented that the
lac
genes carried by F
0
are identical or at least markedly similar to the
lac
genes of
Escherichia coli
K-12. The F
0
transmission factor cannot be precisely identified but it does not appear to be phage or colicin. F
0
does exhibit mutual repression with the sex factor, F, of
E. coli
, and immunological experiments indicate some relationship between F and F
0
.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference31 articles.
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5. Genetic transfer of episomes from Salmonella typhosa to Vibrio cholerae;BARON L. S.;Records Genetics Soc. Am.,1961
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