Affiliation:
1. Microbiology Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
Abstract
As an alternative to exhaustive mapping, an attempt has been made to obtain a rough estimate of the total number of sporulation operons by statistical treatment. Sixteen sporulation mutants taken at random were characterized biochemically and morphologically. The mutations they contained were mapped to determine whether they fell into any one of 23 known operons. From the proportion that do so (10/16), it is calculated that the most probable number of sporulation operons is 37 (68% confidence limits of 31 and 46). If allowance is made for the fact that two of the operons apparently contain mutagenic “hot spots” and the calculation is amended accordingly, the most probable numbers of operons becomes 42 (limits 33 and 59).
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
87 articles.
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