Affiliation:
1. Department of Biochemistry and Microbiology, Rutgers University, New Brunswick, New Jersey 08903
Abstract
Branched- and straight-chain alkanes are metabolized by
Brevibacterium erythrogenes
by means of two distinct pathways. Normal alkanes (e.g.,
n
-pentadecane) are degraded, after terminal oxidation, by the beta-oxidation system operational in fatty acid catabolism. Branched alkanes like pristane (2,6,10,14-tetramethylpentadecane) and 2-methylundecane are degraded as dicarboxylic acids, which also undergo beta-oxidation. Pristane-derived intermediates are observed to accumulate, with time, as a series of dicarboxylic acids. This dicarboxylic acid pathway is not observed in the presence of normal alkanes. Release of
14
CO
2
from [1-
14
C]pristane is delayed, or entirely inhibited, in the presence of
n
-hexadecane, whereas CO
2
release from
n
-hexadecane remains unaffected. These results suggest an inducible dicarboxylic acid pathway for degradation of branched-chain alkanes.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
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