CD8 T Cell Responses to an Immunodominant Epitope within the Nonstructural Protein NS1 Provide Wide Immunoprotection against Bluetongue Virus in IFNAR −/− Mice-Reference-Cited by-同舟云学术

CD8 T Cell Responses to an Immunodominant Epitope within the Nonstructural Protein NS1 Provide Wide Immunoprotection against Bluetongue Virus in IFNAR −/− Mice

Published:2018-08-15 Issue:16 Volume:92 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Marín-López Alejandro¹,Calvo-Pinilla Eva¹,Barriales Diego¹²,Lorenzo Gema¹,Brun Alejandro¹,Anguita Juan²³,Ortego Javier¹^ORCID

Affiliation:

1. Center for Animal Health Research, INIA-CISA, Valdeolmos, Madrid, Spain

2. Macrophage and Tick Vaccine Lab, CIC bioGUNE, Bizkaia Technology Park, Derio, Bizkaia, Spain

3. Ikerbasque, Basque Foundation for Science, Bilbao, Bizkaia, Spain

Abstract

Conventional vaccines have controlled or limited BTV expansion in the past, but they cannot address the need for cross-protection among serotypes and do not allow distinguishing between infected and vaccinated animals (DIVA strategy). There is a need to develop universal vaccines that induce effective protection against multiple BTV serotypes. In this work we have shown the importance of the nonstructural protein NS1, conserved among all the BTV serotypes, in CD8 T cell-mediated protection against multiple BTV serotypes when vectorized as a recombinant MVA vaccine.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00938-18

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