Effect of Viral Double-Stranded RNA on Protein Synthesis in Intact Cells

Author:

Cordell-Stewart B.1,Taylor Milton W.1

Affiliation:

1. Department of Microbiology, Indiana University, Bloomington, Indiana 47401

Abstract

The addition of purified, noninfectious, double-stranded RNA of bovine enterovirus, a picornavirus, to intact cells in culture results in a rapid cessation of cellular polypeptide synthesis. This inhibition is specific for host cell protein synthesis since the translation of picornavirus-specific proteins is not affected by the double-stranded viral RNA.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference16 articles.

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2. Purification and characterization of poliovirus-induced infectious doublestranded RNA;Bishop J. M.;J. Biol. Chem.,1967

3. Characterization of ribonuclease-resistant RNA from poliovirus-infected HeLa cells;Bishop J. M.;Biochemistry,1965

4. The inhibition of f2 RNA directed E. coli protein synthesis by Poly rI rC in vitro;Chao J.;Biochem. Biophys. Res. Commun.,1971

5. Effect of double-stranded viral RNA on mammalian cells in culture;Cordell-Stewart B.;Proc. Nat. Acad. Sci. U.S.A.,1971

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