Structural Organization of Murine Intracisternal A Particles

Author:

Wivel Nelson A.1,Lueders Kira K.1,Kuff Edward L.1

Affiliation:

1. Laboratories of Cell Biology and Biochemistry, National Cancer Institute, Bethesda, Maryland 20014

Abstract

Isolated murine intracisternal A particles have a distinctive set of structural properties as compared to the recognized oncogenic ribonucleic acid tumor viruses. A particles consist of two closely approximated concentric shells. The outer shell is largely, but not entirely, susceptible to treatment with detergents such as deoxycholate and Triton X-100. The inner shell is resistant to these agents and is stabilized against solubilization by sodium dodecyl sulfate as a result of disulfide bonding between its constituent proteins. The major A particle structural protein (molecular weight approximately 70,000) is contained in the inner shell. A protein component with a molecular weight of about 80,000 may be preferentially concentrated in sites of firm attachment between the inner and outer shells.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference13 articles.

1. Some ultrastructural characteristics of a series of primary and transplanted plasma-cell tumors of the mouse;Dalton A. J.;J. Nat. Cancer Inst.,1961

2. Structure of a murine leukemia virus after disruption with tweenether and comparison with two myxoviruses;de The G.;Virology,1966

3. Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane;Fairbanks G.;Biochemistry,1971

4. Some structural and antigenic properties of intracisternal A-particles occurring in mouse tumors;Kuff E. L.;Proc. Nat. Acad. Sci. U.S.A.,1972

5. The extraction of intracisternal A-particles from a mouse plasma-cell tumor;Kuff E. L.;Cancer Res.,1968

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