Evaluation of Diagnostic Accuracy of Eight Commercial Assays for the Detection of Rubella Virus-Specific IgM Antibodies

Author:

Hiebert Joanne1,Zubach Vanessa1,Charlton Carmen L.234,Fenton Jayne2,Tipples Graham A.245,Fonseca Kevin26,Severini Alberto17ORCID

Affiliation:

1. Viral Exanthemata and STD Section, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

2. Public Health Laboratory, Alberta Precision Laboratories, Edmonton, Alberta, Canada

3. Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada

4. Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada

5. Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada

6. Department of Microbiology, Immunology and Infectious Disease, University of Calgary, Calgary, Alberta, Canada

7. Department of Medical Microbiology and Infectious Diseases, Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada

Abstract

Rubella and congenital rubella syndrome are caused by the rubella virus and are preventable through vaccination, making disease eradication possible. Monitoring of progress toward global eradication and local elimination requires high-quality, sensitive disease surveillance that includes laboratory confirmation of cases.

Funder

Public Health Agency of Canada

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference23 articles.

1. Feasibility assessment of measles and rubella eradication

2. Public Health Agency of Canada. 2013. Elimination of measles rubella and congenital rubella syndrome in Canada: Documentation and verification report. Public Health Agency of Canada https://www.canada.ca/en/public-health/services/immunization/vaccine-preventable-diseases/elimination-measles-rubella-congenital-rubella-syndrome-canada-documentation-verification-report.html. Accessed 17 November 2020.

3. World Health Organization. 2013. Framework for verifying elimination of measles and rubella. Wkly Epidemiol Rec 88:89–99. https://www.who.int/publications/i/item/framework-for-verifying-elimination-of-measles-and-rubella.

4. World Health Organization. 2017. Roadmap to elimination standard measles and rubella surveillance. Wkly Epidemiol Rec 92:97–105. https://apps.who.int/iris/bitstream/handle/10665/254754/WER9209_10-97-105.pdf.

5. Dilemmas and Pitfalls in Rubella Laboratory Diagnostics in Low Prevalence or Elimination Settings

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