Hiding in Plain Sight: an Approach to Treating Patients with Severe COVID-19 Infection-Reference-Cited by-同舟云学术

Hiding in Plain Sight: an Approach to Treating Patients with Severe COVID-19 Infection

Published:2020-04-28 Issue:2 Volume:11 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Fedson David S.¹,Opal Steven M.²,Rordam Ole Martin³

Affiliation:

1. 57, chemin du Lavoir, Sergy Haut, France

2. Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA

3. Fyordgata 59, Trondheim, Norway

Abstract

Patients with COVID-19 infection are at risk of acute respiratory disease syndrome (ARDS) and death. The tissue receptor for COVID-19 is ACE2, and higher levels of ACE2 can protect against ARDS. Angiotensin receptor blockers and statins upregulate ACE2. Clinical trials are needed to determine whether this drug combination might be used to treat patients with severe COVID-19 infection.

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00398-20

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