Clonal Relatedness of Erythromycin-Resistant Streptococcus pyogenes Isolates in Germany

Author:

Reinert Ralf R.1,Lütticken Rudolf1,Sutcliffe Joyce A.2,Tait-Kamradt Amelia3,Cil Murat Y.1,Schorn Holger M.1,Bryskier André4,Al-Lahham Adnan1

Affiliation:

1. Institute for Medical Microbiology, National Reference Center for Streptococci, University Hospital, D-52057 Aachen, Germany

2. Rib-X Pharmaceuticals, New Haven

3. Pfizer Central Research and Development, Groton, Connecticut

4. Aventis Pharma, Hoechst Marion Roussel, Romainville, France

Abstract

ABSTRACT In a nationwide study in Germany, a total of 381 Streptococcus pyogenes were collected. Erythromycin A-resistant strains were characterized for the underlying resistance genotype, showing 55.6% had the efflux type mef (A), 31.5% had erm (A), and 13.0% had erm (B). A total of 23 different multilocus sequence types were observed.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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