Hypoglycemic Activity of Endotoxin II. Mechanism of the Phenomenon in BCG-infected Mice-Reference-Cited by-同舟云学术

Hypoglycemic Activity of Endotoxin II. Mechanism of the Phenomenon in BCG-infected Mice

Published:1969-05 Issue:2 Volume:98 Page:494-501
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Shands J. W.¹,Miller V.¹,Martin H.¹,Senterfitt V.¹

Affiliation:

1. Department of Microbiology, College of Medicine, University of Florida, Gainesville, Florida 32601

Abstract

The mechanism of the hypoglycemic activity of endotoxin in hyperreactive BCG mice was investigated. The mechanism was found to be an inhibition of the synthesis of glucose from noncarbohydrate sources. The possibilities of an induced hypermetabolic state and an induced release of insulin in response to endotoxin as causes for the hypoglycemic response were essentially ruled out. In addition, no clear-cut evidence of an insulin-like action by endotoxin was found in the in vivo setting.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.98.2.494-501.1969

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