Mycophenolic Acid and Its Derivatives as Potential Chemotherapeutic Agents Targeting Inosine Monophosphate Dehydrogenase in Trypanosoma congolense-Reference-Cited by-同舟云学术

Mycophenolic Acid and Its Derivatives as Potential Chemotherapeutic Agents Targeting Inosine Monophosphate Dehydrogenase in Trypanosoma congolense

Published:2016-07 Issue:7 Volume:60 Page:4391-4393
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Suganuma Keisuke¹,Sarwono Albertus Eka Yudistira²,Mitsuhashi Shinya²,Jąkalski Marcin³,Okada Tadashi¹⁴,Nthatisi Molefe¹,Yamagishi Junya⁵,Ubukata Makoto²,Inoue Noboru¹

Affiliation:

1. National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido, Japan

2. Division of Applied Bioscience Research, Graduate School of Agriculture, Hokkaido University, Sapporo, Hokkaido, Japan

3. Institute of Bioinformatics, Faculty of Medicine, University of Münster, Münster, Germany

4. Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Aichi, Japan

5. Division of Collaboration and Education, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Hokkaido, Japan

Abstract

ABSTRACT This study aimed to evaluate the trypanocidal activity of mycophenolic acid (MPA) and its derivatives for Trypanosoma congolense . The proliferation of T. congolense was completely inhibited by adding <1 μM MPA and its derivatives. In addition, the IMP dehydrogenase in T. congolense was molecularly characterized as the target of these compounds. The results suggest that MPA and its derivatives have the potential to be new candidates as novel trypanocidal drugs.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02816-15

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