Affiliation:
1. Department of Experimental Therapeutics, Roswell Park Memorial Institute, Buffalo, New York 14203
Abstract
Regulation of intracellular proteolysis has been compared during amino acid deficiencies in seven double auxotrophs of
Escherichia coli
9723f with a common phenylalanine requirement. Individual deficiencies were either more effective than, less effective, or equal to phenylalanine deficiency in stimulating intracellular proteolysis. For each amino acid, the same relationship prevailed in inhibiting uracil incorporation into nucleic acids, a reaction series regulated by the
rel
gene for stringent control. The three amino acids least abundant in the cellular protein were the least effective regulators. These findings are interpreted as supportive evidence for stringent control of intracellular proteolysis by the
rel
gene.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference26 articles.
1. Optimal conditions for mutagenesis by N-methyl-N'- nitro-N-nitrosoguanidine in Escherichia coli;Adelberg E. A.;Biochem. Biophys. Res. Commun.,1965
2. Bacteriophage QBt replicase contains the protein biosynthesis elongation factors EFTu and EFTs;Blumenthal T.;Proc. Nat. Acad. Sci. U.S.A.,1972
3. Synthesis and breakdown of proteins in Escherichia coli during amino acid starvation;Brunschede H.;J. Mol. Biol.,1971
4. The control of ribonucleic acid synthesis in Escherichia coli. IV. Relevance of unusual phosphorylated compounds from amino acid-starved stringent cells;Cashel M.;J. Biol. Chem.,1969
5. Physiology and genetics of the "ribonucleic acid control;Edlin G.;Bacteriol. Rev.,1968
Cited by
16 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献